Generation of Parkinson's disease patient-derived human induced pluripotent stem cells line (PNUSCRi001-A) carrying a N227S mutation in GBA gene

Summary

The hiPSC line was generated from peripheral blood mononuclear cells (PBMCs) collected by a male patient with young onset Parkinson's disease, carrying on heterozygous c.680 A > G (N227S) mutation in the GBA gene. The PBMCs was reprogrammed into an induced pluripotent stem cell (iPSC) line (PNUSCRi001-A hiPSCs) using non-integrative sendai virus. The hiPSC line, PNUSCRi001-A displayed a normal karyotype and the Expression of pluripotency markers that is capable of producing derivatives of three germ layers (Ectoderm, Endoderm and Mesoderm). Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Lee N, Moon HJ, Park SH, Moon JY, Park KK, Kim JH, Lee JH
Journal Stem cell research
Publication Date 2022 Oct 31;65:102959
PubMed 36332465
DOI 10.1016/j.scr.2022.102959

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