Generation of Parkinson's disease patient-derived human induced pluripotent stem cells line (PNUSCRi001-A) carrying a N227S mutation in GBA gene
Summary
The hiPSC line was generated from peripheral blood mononuclear cells (PBMCs) collected by a male patient with young onset Parkinson's disease, carrying on heterozygous c.680 A > G (N227S) mutation in the GBA gene. The PBMCs was reprogrammed into an induced pluripotent stem cell (iPSC) line (PNUSCRi001-A hiPSCs) using non-integrative sendai virus. The hiPSC line, PNUSCRi001-A displayed a normal karyotype and the Expression of pluripotency markers that is capable of producing derivatives of three germ layers (Ectoderm, Endoderm and Mesoderm). Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Lee N, Moon HJ, Park SH, Moon JY, Park KK, Kim JH, Lee JH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Dec;65:102959 |
| PubMed | 36332465 |
| DOI | 10.1016/j.scr.2022.102959 |