Human induced pluripotent stem cells generated from a 45-years-old male donor of type 2 diabetes mellitus with APOE-epsilon3/epsilon3 alleles


Apolipoprotein E (APOE) gene encodes three protein isoforms (APOEε-22/ε-33/ε-44), which governs the transportation and metabolism of lipoproteins differently. While abnormalities in lipid and lipoprotein metabolism have been identified as risk factors for type 2 diabetes mellitus (T2DM). APOE gene polymorphisms might be correlated with increased risk of T2DM. Therefore, we presented an iPSC line harboring an APOE-ε3/ε3 alleles, a male donor suffering from T2DM combined with Hypertension. The derived iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes. Collectively, the present study provides a useful resource to reveal the associated mechanism of APOE isoform and T2DM. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Cao S, Guo R, Zhang J, Liu X, Zhou Z, Song Y, Ma J
Journal Stem cell research
Publication Date 2022 Jun 9;63:102840
PubMed 35717858
DOI 10.1016/j.scr.2022.102840

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