Generation of multiple iPSC clones from a male schizophrenia patient carrying de novo mutations in genes KHSRP, LRRC7, and KIR2DL1, and his parents
Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father - of a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified in the proband. Peripheral blood mononuclear cells were obtained from all three individuals and reprogrammed using Sendai virus particles carrying the Yamanaka transgenes. These 3 iPSC lines (iPSC-SZ-HU-MO 1, iPSC-SZ-HU-FA 1, and iPSC-SZ-HU-PROB 1) represent a resource for examining the functional significance of the identified de novo mutations in the molecular pathophysiology of schizophrenia. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
|Authors||Hathy E, Szabó E, Vincze K, Haltrich I, Kiss E, Varga N, Erdei Z, Várady G, Homolya L, Apáti Á, Réthelyi JM|
|Journal||Stem cell research|
|Publication Date||2021 Mar;51:102140|