Generation of multiple iPSC clones from a male schizophrenia patient carrying de novo mutations in genes KHSRP, LRRC7, and KIR2DL1, and his parents
Summary
Here we describe the generation of induced pluripotent stem cell lines from each member - male proband, mother, father - of a schizophrenia case-parent trio that participated in an exome sequencing study, and 3 de novo mutations were identified in the proband. Peripheral blood mononuclear cells were obtained from all three individuals and reprogrammed using Sendai virus particles carrying the Yamanaka transgenes. These 3 iPSC lines (iPSC-SZ-HU-MO 1, iPSC-SZ-HU-FA 1, and iPSC-SZ-HU-PROB 1) represent a resource for examining the functional significance of the identified de novo mutations in the molecular pathophysiology of schizophrenia. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Hathy E, Szabó E, Vincze K, Haltrich I, Kiss E, Varga N, Erdei Z, Várady G, Homolya L, Apáti Á, Réthelyi JM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Mar;51:102140 |
| PubMed | 33503521 |
| DOI | 10.1016/j.scr.2020.102140 |