Generation of human iPSC line from a patient with Tetralogy of Fallot, YAHKMUi001-A, carrying a mutation in TBX1 gene
Summary
The human induced pluripotent stem cell (iPSC) line YAHKMUi001-A was derived from the dermal fibroblasts of a patient with Tetralogy of Fallot (TOF), with a mutation in the TBX1 gene (c.928G > A). The skin fibroblasts were obtained from a 4-year-old boy, and were infected with Sendai virus expressing the Yamanaka factors. The YAHKMUi001-A iPSC line expresses pluripotent stem cell markers, displays a normal karyotype, and has the capacity to differentiate into 3 germ layers. This cell line model can be a good tool to study the pathological mechanism of the TBX1 gene mutations associated with TOF. Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Han S, Zhang YY, Meng MY, Hou ZL, Meng P, Zhao YY, Gao H, Tang J, Liu Z, Yang LL, Jiang LH, Li YX |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2020 Jan;42:101687 |
| PubMed | 31869684 |
| DOI | 10.1016/j.scr.2019.101687 |