Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation


Epilepsy is a common chronic neurological disorder related to genetic factors. Base on the non-integrating episomal vector technique, a human induced pluripotent stem cell (iPSC) line, termed as LZUSHI001-A, was generated from peripheral blood mononuclear cells (PBMCs) of a 11-year-old male patient with Epilepsy, who had a heterozygous (c.2042G>A, p.R681Q) mutation in the DGKG gene. LZUSHI001-A offers a useful resource to investigate pathogenic mechanisms in epilepsy, as well as a cell-based model for drug development to treat epilepsy. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Liu YQ, Ling TW, Wang HY, Yang YH, Song WJ, Wang TC
Journal Stem cell research
Publication Date 2022 May;61:102768
PubMed 35421845
DOI 10.1016/j.scr.2022.102768

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