Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation
Summary
Epilepsy is a common chronic neurological disorder related to genetic factors. Base on the non-integrating episomal vector technique, a human induced pluripotent stem cell (iPSC) line, termed as LZUSHI001-A, was generated from peripheral blood mononuclear cells (PBMCs) of a 11-year-old male patient with Epilepsy, who had a heterozygous (c.2042G>A, p.R681Q) mutation in the DGKG gene. LZUSHI001-A offers a useful resource to investigate pathogenic mechanisms in epilepsy, as well as a cell-based model for drug development to treat epilepsy. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Liu YQ, Ling TW, Wang HY, Yang YH, Song WJ, Wang TC |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 May;61:102768 |
| PubMed | 35421845 |
| DOI | 10.1016/j.scr.2022.102768 |