Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79-year-old patient with Alzheimer's disease having APOE3/4 genetic background


The genotype of apolipoprotein E (APOE) is closely associated with susceptibility to Alzheimer's disease. Here, we described the generation and characterization of human induced pluripotent stem cells from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient with Alzheimer's disease having APOE3/4 genotype. The generated iPSCs expressed pluripotent stem cell markers that were observed using immunocytochemistry. Moreover, they displayed a normal karyotype and had the potential to differentiate spontaneously into three germ layers in vitro. Our model could provide valuable insights into pathological mechanisms, and offer a unique opportunity for developing drugs against specific phenotypes for Alzheimer's disease therapy. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Dai Q, Zhang W, Guo J, Di W, Zhao J, Zhang B, Wang Y
Journal Stem cell research
Publication Date 2020 Oct;48:101949
PubMed 32822964
DOI 10.1016/j.scr.2020.101949

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