Establishment of a human induced pluripotent stem cell line (SDQLCHi005-A) from a patient with mastocytosis carrying heterozygous mutation in KIT gene
Summary
We established an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells of a Chinese neonate with mastocytosis carrying heterozygous mutation (c.2447A > T (p.D816V)) in KIT gene by episomal vector (EV) reprogramming system. This iPSC line carrying KIT gene mutation, was free of exogenous gene, showed a normal karyotype, expressed pluripotency markers and exhibited differentiation potential. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zhang H, Ma Y, Yan B, Yang X, Li Y, Guan J, Dong R, Liu Y, Gai Z |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2019 Oct;40:101565 |
| PubMed | 31522012 |
| DOI | 10.1016/j.scr.2019.101565 |