Generation of a human-derived induced pluripotent stem cell line (SIAISi012-A) from an 82-year-old healthy Chinese Han male


As the global median population age increases, neurological diseases associated with aging pose significant challenges to human health. Appropriate modeling systems can be useful tools to better understand the mechanism of age-related neuronal degeneration diseases. Here, we successfully generated an iPSC-derived modeling system of an 82-year-old healthy man, this newly established line showed that all pluripotent markers were expressed, and the differentiation potential was confirmed by trilineage differentiation. STR profiling proved the cell line identity, and G-binding showed the normal karyotype. Copyright © 2021. Published by Elsevier B.V.

Authors Guo J, Fang F, Dai Q, Zhang W, Di W, Hu J, Zhao J, Cao J, Wang Y
Journal Stem cell research
Publication Date 2021 Apr;52:102186
PubMed 33610016
DOI 10.1016/j.scr.2021.102186

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