A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity


Circ-INSR is a highly conserved non-coding RNA which is down-regulated during cardiotoxicity and cardiac remodelling. Adeno-associated virus and circRNA mimics-based Circ-INSR overexpression prevent and reverse doxorubicin-mediated cardiomyocyte death and improve cardiac function. The results of this study highlight a novel and translationally important Circ-INSR-based therapeutic approach for doxorubicin-induced cardiac dysfunction. © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology.

Authors Lu D, Chatterjee S, Xiao K, Riedel I, Huang CK, Costa A, Cushman S, Neufeldt D, Rode L, Schmidt A, Juchem M, Leonardy J, Büchler G, Blume J, Gern OL, Kalinke U, Wen Tan WL, Foo R, Vink A, van Laake LW, van der Meer P, Bär C, Thum T
Journal European heart journal
Publication Date 2022 Nov 7;43(42):4496-4511
PubMed 35758064
PubMed Central PMC9637424
DOI 10.1093/eurheartj/ehac337

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