A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity
Summary
Circ-INSR is a highly conserved non-coding RNA which is down-regulated during cardiotoxicity and cardiac remodelling. Adeno-associated virus and circRNA mimics-based Circ-INSR overexpression prevent and reverse doxorubicin-mediated cardiomyocyte death and improve cardiac function. The results of this study highlight a novel and translationally important Circ-INSR-based therapeutic approach for doxorubicin-induced cardiac dysfunction. © The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology.
| Authors | Lu D, Chatterjee S, Xiao K, Riedel I, Huang CK, Costa A, Cushman S, Neufeldt D, Rode L, Schmidt A, Juchem M, Leonardy J, Büchler G, Blume J, Gern OL, Kalinke U, Wen Tan WL, Foo R, Vink A, van Laake LW, van der Meer P, Bär C, Thum T |
|---|---|
| Journal | European heart journal |
| Publication Date | 2022 Nov 7;43(42):4496-4511 |
| PubMed | 35758064 |
| PubMed Central | PMC9637424 |
| DOI | 10.1093/eurheartj/ehac337 |