Generation of induced pluripotent stem cells FIRDIi001-A from a Taiwanese subject carrying ALDH2 pE487K mutation
Summary
The ALDH2 mutation (ALDH2*2) is caused by an amino acid substitution ALDH2 rs671 G>A (pE487K) which reduces ALDH2 enzyme activity. When individuals with the ALDH2 mutation consume alcohol, accumulating acetaldehyde in the blood can cause reddened face, headache, nausea, and palpitations; symptoms referred to as Alcohol Flushing Reaction. We report the production of an induced pluripotent stem cell (iPSC) line, FIRDIi001-A, developed from peripheral blood mononuclear cells of a 39-year-old male subject with the ALDH2*2 mutation. The ALDH2-pE487K iPSCs will be valuable in investigating pathogenic mechanisms involved in the link between the ALDH2 polymorphism and alcohol-related diseases. Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Lu HE, Pan YL, Ko HW, Hsu SH, Wen CH, Hsu YC |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Apr;52:102229 |
| PubMed | 33592568 |
| DOI | 10.1016/j.scr.2021.102229 |