Generation of two human induced pluripotent stem cell lines, UNIBSi012-A and UNIBSi013-A, from two patients with treatment-resistant depression


Novel and complementary experimental models are required for investigating the molecular mechanisms underlying the resistance to the available therapies of patients with major depression (Treatment-Resistant Depression, TRD) that occurs in at least one third of patients and need to be deeply investigated. Here, we have established a patient-specific disease model for TRD by reprogramming peripheral blood mononuclear cells (PBMCs) from two TRD patients into induced pluripotent stem cells (iPSCs), using non-integrating Sendai virus. These lines show the typical morphology of pluripotent cells, express pluripotency markers and displayed in vitro differentiation potential toward cells of the three embryonic germ layers. Copyright © 2020. Published by Elsevier B.V.

Authors Bono F, Mutti V, Piovani G, Minelli A, Mingardi J, Guglielmi A, Fiorentini C, Barbon A, Missale C, Gennarelli M
Journal Stem cell research
Publication Date 2020 Dec;49:102104
PubMed 33291010
DOI 10.1016/j.scr.2020.102104

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