Generation of a human induced pluripotent stem cell line PUMCHi017-A from a Choroideremia patient with CHM mutation

Summary

Choroideremia (CHM) is a rare monogenic, X-linked recessive inherited chorioretinal dystrophy caused by loss of function variants in the CHM gene. We successfully generated a novel human induced pluripotent stem cell (hiPSC) line from a CHM patient with CHM variant using the Sendai-virus based approach. These cells will provide a disease model for further studies on the disease pathogenesis and potential interventions. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Han X, Wu S, Sun Z, Zhu T, Wei X, Zou X, Sui R
Journal Stem cell research
Publication Date 2022 Jan 10;59:102661
PubMed 35032821
DOI 10.1016/j.scr.2022.102661

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