Generation of a human induced pluripotent stem cell line PUMCHi017-A from a Choroideremia patient with CHM mutation
Choroideremia (CHM) is a rare monogenic, X-linked recessive inherited chorioretinal dystrophy caused by loss of function variants in the CHM gene. We successfully generated a novel human induced pluripotent stem cell (hiPSC) line from a CHM patient with CHM variant using the Sendai-virus based approach. These cells will provide a disease model for further studies on the disease pathogenesis and potential interventions. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
|Authors||Han X, Wu S, Sun Z, Zhu T, Wei X, Zou X, Sui R|
|Journal||Stem cell research|
|Publication Date||2022 Jan 10;59:102661|