Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection


Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Mishra K, Junday K, Wong CMY, Chan AY, Hesselson S, Muller DW, Iismaa SE, Mehta A, Graham RM
Journal Stem cell research
Publication Date 2019 Dec;41:101584
PubMed 31707208
DOI 10.1016/j.scr.2019.101584

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