Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection
Summary
Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44-55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Mishra K, Junday K, Wong CMY, Chan AY, Hesselson S, Muller DW, Iismaa SE, Mehta A, Graham RM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2019 Dec;41:101584 |
| PubMed | 31707208 |
| DOI | 10.1016/j.scr.2019.101584 |