Human induced pluripotent stem cells generated from a patient with a homozygous mutation in the Lyn kinase gene
Summary
We have successfully generated induced pluripotent stem cells (iPSC) from dermal fibroblasts of the patient with a germline mutation in the coding region of the LYN kinase gene. This gain of function (GOF) mutation eliminates the inhibitory tyrosine (Y) at the position p.Y508, with an unknown established disease etiology. The iPSC carrying germline mutation in LYN are phenotypically normal, and they have capacity to differentiate toward the three germ layers. These iPSCs are critical for studying this unknown disease etiology and to the further understand the role of Lyn kinases in autoimmune disease. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Harper R, Yu Q, Liu Y, Yang D, Zou J, Beers J, de Jesus Rasheed AA, Goldbach-Mansky R, Boehm M, Chen G |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Oct;64:102933 |
| PubMed | 36215934 |
| PubMed Central | PMC9674432 |
| DOI | 10.1016/j.scr.2022.102933 |