IMEDEAi006-A

Registration Summary:

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General

iPSC Line
hPSCreg name	IMEDEAi006-A
Cite as:	IMEDEAi006-A (RRID:CVCL_WK45)
iPSC line type	Human induced pluripotent stem cell (hiPSC)
Similar iPSC lines	No similar lines found.
Last update	26th February 2019
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Provider
Generator	Instituto Mediterraneo de Estudios Avanzados (IMEDEA)
External iPSC Databases
Cellosaurus	CVCL_WK45
Wikidata	Q94316126
General iPSC Information
Publications	Vallejo-Diez S et al. Generation of one iPSC line (IMEDEAi006-A) from an early-onset familial Alzheimer's Disease (fAD) patient carrying the E280A mutation in the PSEN1 gene. Stem cell research. 2019 May;37:101440. Vélez JI et al. Familial Alzheimer's Disease and Recessive Modifiers. Molecular neurobiology. 2020 Feb;57(2):1035-1043. Vallejo-Diez S et al. Generation of a human iPSC line (IMEDEAi008-A) derived from natural homozygous CCR5-Δ32 PBMCs enriched in the pro-erythroblast population. Stem cell research. 2020 Aug;47:101918. Meng-Jie L.. Application progress of induced pluripotent stem cells in Alzheimer's disease. . 2021-02-28. Mendivil-Perez Miguel et al. PSEN1 E280A Cholinergic-like Neurons and Cerebral Spheroids Derived from Mesenchymal Stromal Cells and from Induced Pluripotent Stem Cells Are Neuropathologically Equivalent. International Journal of Molecular Sciences. 2023-05-18. Gomez-Sequeda Nicolas et al. Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology. Scientific Reports. 2023-08-08. Giraldo-Berrio Daniela et al. Minocycline mitigates Aβ and TAU pathology, neuronal dysfunction, and death in the PSEN1 E280A cholinergic-like neurons model of familial Alzheimer’s disease. Neuropharmacology. 2024-12-00.

iPSC Derivation

General