Insulin regulates human pancreatic endocrine cell differentiation in vitro
Summary
Using iPSC disease modelling, we provide first evidence of insulin function in human pancreatic endocrine lineage formation. These findings help to better understand the phenotypic impact of recessive insulin gene mutations during pancreas development and shed light on insulin gene function beside its physiological role in blood glucose regulation. Copyright © 2023 The Author(s). Published by Elsevier GmbH.. All rights reserved.
| Authors | Cota P, Caliskan ÖS, Bastidas-Ponce A, Jing C, Jaki J, Saber L, Czarnecki O, Taskin D, Blöchinger AK, Kurth T, Sterr M, Burtscher I, Krahmer N, Lickert H, Bakhti M |
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| Journal | Molecular metabolism |
| Publication Date | 2024 Jan;79:101853 |
| PubMed | 38103636 |
| PubMed Central | PMC10765254 |
| DOI | 10.1016/j.molmet.2023.101853 |