Generation of two iPSC lines, (ICGi015-A and ICGi015-B), by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease


Studying Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, requires different model systems, including patient-specific induced pluripotent stem cell lines. With the help of non-integrating episomal vectors the iPSC lines ICGi015-A and ICGi015-B were generated from blood mononuclear cells of PD patient, carrying three SNPs, associated with PD development. The obtained iPSC lines express pluripotency markers and demonstrate the ability to in vitro differentiate into the three germ layers. These cell lines may be useful for studying molecular mechanisms of PD and for drug screening. Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Sharipova DV, Kovalenko VR, Bairamova EM, Vartanova VA, Grigor'eva EV, Vyatkin YV, Khabarova EA, Rzaev DA, Zakian SM, Medvedev SP
Journal Stem cell research
Publication Date 2019 Dec;41:101652
PubMed 31733442
DOI 10.1016/j.scr.2019.101652

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