Generation of induced pluripotent stem cell line from a patient with long COVID
Summary
Long COVID, or post-acute sequelae of SARS-CoV-2 infection, leads to vascular dysfunction, which contributes to the chronic multi-organ damage often seen in affected patients. Long COVID, a global health concern is associated with increased thrombotic risk, also known as COVID-19-associated coagulopathy (CAC). Here, we derived an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMCs) of a long COVID patient. This iPSC line showed normal morphology, maintained pluripotency, had a stable karyotype, and demonstrated the ability to differentiate into the three germ layers (ectoderm, endoderm, and mesoderm). This line provides a valuable tool for modeling long COVID and exploring mechanisms underlying multi-organ dysfunction. Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Wu D, Manhas A, Noishiki C, Tripathi D, Liu L, Turbes N, Thomas D, Sallam K, Lee JT, Sayed N |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Mar;83:103652 |
| PubMed | 39823918 |
| PubMed Central | PMC11913185 |
| DOI | 10.1016/j.scr.2025.103652 |