BIONi010-C-38

Registration Summary:

A P E C

APP KM670/671NL (Swedish mutation)

The cell line is not submitted yet.

(only basic data is shown)

General

Cell Line
hPSCreg name	BIONi010-C-38
Cite as:	BIONi010-C-38 (RRID:CVCL_UR27)
Alternative name(s)	APP KM670/671NL (Swedish mutation)
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	7th March 2023
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Provider
Generator	Bioneer (BION)
External Databases
Cellosaurus	CVCL_UR27
Wikidata	Q93426795
General Information
Publications	Frederiksen HR et al. Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene. Stem cell research. 2019 Jan;34:101368. Lim CM et al. Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation. Proceedings of the National Academy of Sciences of the United States of America. 2023 Oct 3;120(40):e2300215120. Díaz Alicia González et al. A human neuronal model of sporadic Alzheimer’s disease induced byFBXO2downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment. . 2024-09-03.
* Is the cell line readily obtainable for third parties?	Yes Research use: allowed Clinical use: not allowed Commercial use: not allowed
Subclone of	BIONi010-C

hIPSC Derivation

General
The source cell information can be found in the parental cell line BIONi010-C.