Bioneer (BION)

Cell lines

• BIONi010-A (K1P53)
• BIONi010-B (BIONi010-B, K2P53)
• BIONi010-C (BIONi010-C, K3P53)
• BIONi013-A (H240715 47-1, SAMEA4342502)
• BIONi014-A (H270715 47-1, SAMEA4342566)
• BIONi015-A (H280715 47-1, SAMEA4342649)
• BIONi016-A (H310715 47-1)
• BIONi010-C-2 (BIONi010-C ApoE E3/E3 #H8 P32)
• BIONi010-C-3 (BIONi010-C ApoE KO #KO30 P30)
• BIONi017-A (H030815 47-1, SAMEA4451663)
• BIONi018-A (H050815 48-4, SAMEA4451665)
• BIONi019-A (H060815 48-3, SAMEA4451667)
• BIONi020-A (H070815 47-2, SAMEA4451669)
• BIONi021-A (H100815 48-2, SAMEA4451671)
• BIONi022-A (H110815 47-2, SAMEA4451673)
• BIONi010-C-4 (BIONi010-C ApoE E4/E4 #B44 P27)
• BIONi010-C-5 (BIONi010-C CD33 E2del #N14 P26)
• BIONi023-A (H130815 47-4, SAMEA4454014)
• BIONi024-A (H170815 47-2, SAMEA4454016)
• BIONi025-A (H210815 48-3, SAMEA4454018)
• BIONi010-C-6 (BIONi010-C ApoE E2/E2)
• BIONi010-C-7 (BIONi010-C Trem2 R47H)
• BIONi010-C-8 (#Y5-80, BIONi010-C Trem2 T66M)
• BIONi010-C-9 (BIONi010-C CD33 KO)
• BIONi026-A (H300715 48-3)
• BIONi027-A (H040815 48-1, SAMEA4455499)
• BIONi028-A (H120815 48-1, SAMEA4455501)
• BIONi029-A (H190815 47-1, SAMEA4455503)
• BIONi030-A (H200815 47-1, SAMEA4455505)
• BIONi031-A (H240815 48-2, SAMEA4455507)
• BIONi032-A (H250815 48-1, SAMEA4455509)
• BIONi033-A (H180615, SAMEA4563389)
• BIONi034-A (H290715, SAMEA4563391)
• BIONi035-A (H180815, SAMEA4563393)
• BIONi010-C-10 (HNF1AP291fsinsC +/- 54-5)
• BIONi010-C-11 (HNF1AP291fsinsC -/- 66-1)
• BIONi010-C-12 (HNF4ApR309C -/- 2-4)
• BIONi036-A (11599)
• BIONi037-A (16423 ApoE3/3 (control line))
• BIONi010-C-13 (BIONi010-C + NGN2 #I7-26)
• BIONi010-C-15 (BIONi010-C +dox inducible NGN2-GFP)
• BIONi037-A-1 (16423 ApoE KO)
• BIONi037-A-2 (BIONi037-A ApoE2/2 #M10-7)
• BIONi037-A-3 (BIONi037-A ApoE3/4 #P10-22)
• BIONi037-A-4 (BIONi037-A ApoE4/4 #I10-53)
• STBCi006-A-1 (ApoE KO)
• UKBi011-A-1 (iLB-AD + ApoE KO)
• UKBi011-A-2 (ApoE 2/2)
• UKBi011-A-3 (ApoE 3/3)
• UKBi011-A-4 (ApoE 3/4)
• STBCi006-A-3 (ApoE 3/3)
• STBCi006-A-4 (ApoE 3/4)
• BIONi010-C-17 (BIONi010-C TREM2 KO)
• BIONi010-C-18 (BIONi010-C TBK1 KO)
• BIONi010-C-19 (BIONi010-C IKBKE KO)
• BIONi010-C-20 (BIONi010-C dox MAPT 2N4R)
• BIONi010-C-21 (BIONi010-C dox MAPT 2N4R P301L)
• BIONi010-C-22 (BIONi010-C MAPT Exon 10+16)
• BIONi010-C-23 (BIONi010-C heterozygous MAPT P301L mutation)
• BIONi010-C-24 (BIONi010-C Dox a-syn)
• BIONi011-B (H170615 C1)
• BIONi011-C (H170615 C4)
• BIONi010-C-25 (BIONi010-C heterozygous TREM2 KO)
• BIONi010-C-26 (BIONi010-C +/- MAPT P301L + NGN2)
• BIONi010-C-27 (BIONi010-C +/+ MAPT E10+16 + NGN2)
• BIONi010-C-28 (BIONi010-C + Cas9 (dox inducible))
• BIONi010-C-29 (BIONi010-C + Psen1 E280A +/+)
• BIONi010-C-30 (BIONi010-C + PSEN1 E280A +/-)
• BIONi010-C-31 (BIONi010-C TREM2 R47H +/-)
• BIONi010-C-32 (BIONi010-C APO E4/E4 PSEN1 L150 +/+ NGN2)
• BIONi010-C-33 (BIONi010-C APOE 2/2 NGN2)
• BIONi010-C-34 (BIONi010-C APOE 4/4 NGN2)
• BIONi010-C-35 (BIONi010-C APOE KO NGN2)
• BIONi010-C-36 (BIONi010-C + APOE 2/2 + Psen1 L150P (+/+) + NGN2)
• BIONi010-C-37 (APP V717I (London mutation))
• BIONi010-C-38 (APP KM670/671NL (Swedish mutation))
• BIONi037-A-5 (V717I (London mutation))
• BIONi037-A-6 (BIONi037-A + APOE KO + NGN2)
• BIONi037-A-7 (BIONi037-A + APOE 2/2 + NGN2)
• BIONi037-A-8 (BIONi037-A + APOE 3/3 + NGN2)
• BIONi037-A-9 (BIONi037-A + APOE 3/4 + NGN2)
• BIONi037-A-10 (BIONi037-A + APOE 4/4 + NGN2)
• UKBi011-A-5 (UKBi011-A + APOE KO + NGN2)
• UKBi011-A-6 (UKBi011-A + APOE 2/2 + NGN2)
• UKBi011-A-7 (UKBi011-A + APOE 3/3 + NGN2)
• UKBi011-A-8 (UKBi011-A + APOE 3/4 + NGN2)
• UKBi011-A-9 (UKBi011-A + APOE 4/4 + NGN2)
• BIONi010-C-39 (BIONi010-C +/- Psen1 E280A + NGN2)
• BIONi010-C-40 (BIONi010-C +/+ Psen1 E280A + NGN2)
• BIONi010-C-41 (BIONi010-C + iNGN2 Two-plasmid system/CRISPR-2)
• SIGi001-A-14 (SIGi001-A Bi-Allelic MAPT HA-tag)
• SIGi001-A-15 (SIGi001-A Dox inducible NGN2)
• SIGi001-A-16 (SIGi001-A-9 Bi-Allelic MAPT HA-tag)
• SIGi001-A-17 (SIGi001-A-9 Dox inducible NGN2)
• SIGi001-A-18 (SIGi001-A-12 Bi-Allelic MAPT HA-tag #U28-12-P29-5)
• SIGi001-A-19 (SIGi001-A-12 Dox inducible NGN2)
• BIONi010-C-42 (BIONi010-C + iCRE AAVS1)
• BIONi010-C-43 (BIONi010-C + aSNCA-wt AAVS1)
• BIONi010-C-44 (BIONi010-C + aSNCA-A53T AAVS1)
• BIONi010-C-45 (BIONi010-C iCRE AAVS1 GBA1 LoxP EX5-6)
• BIONi010-C-48 (BIONi010-C hMDR1)
• BIONi010-C-49 (BIONi010-C + synapsin-m2rtTA + SNCA-wt)
• BIONi010-C-50 (BIONi010-C + synapsin-m2rtTA + SNCA-A53T)
• RCi004-A-1 (RCi004-A + HTT GC #H34-32_T34-23)
• BIONi010-C-51 (BIONi010-C TNNI3-mCherry reporter)
• BIONi010-C-52 (BIONi010-C with an APOE 2/2 genotype (with two functional alleles in contrast to BIONi010-C-6))
• BIONi010-C-53 (BIONi010-C with an APOE 3/3 genotype (with two functional alleles in contrast to BIONi010-C-2))
• BIONi010-C-54 (BIONi010-C with an APOE 4/4 genotype (with two functional alleles in contrast to BIONi010-C-4))
• UKBi011-A-11
• UKBi011-A-12
• UKBi011-A-13
• BIONi010-C-55 (BIONi010-C TNNI3-mCherry/TNNI1-EGFP dual reporter cl. 74)
• BIONi010-C-64 (BIONi010-C-T2A-Nanoluciferase reporter cl. 29)
• BIONi010-C-70 (BIONi010-C with an APOE 2/2 genotype with an additional, homozygous christchurch mutation)
• BIONi010-C-71 (BIONi010-C with an APOE 3/3 genotype with an additional, homozygous christchurch mutation)
• BIONi010-C-72
• BIONi010-C-73
• BIONi010-C-74 (#CL480-A9)
• BIONi010-C-75
• BIONi010-C-76
• BIONi010-C-77
• SIGi001-A-31
• BIONi010-C-78
• SIGi001-A-32
• SIGi001-A-33 (SIGi001-A-15 SNCA KO)
• BIONi010-C-79
• BIONi010-C-80
• BIONi010-C-81
• BIONi037-A-11
• BIONi037-A-12
• BIONi037-A-13
• BIONi037-A-14
• BIONi010-C-82 (BIONi010-C + CLYBL-NGN2-GFP into BIONi010-C-21 (2N4R-MAPT-P301L))
• BIONi010-C-83 (BIONi010-C + AAVS1-CRE (with insulators) #CL559-1)
• BIONi010-C-84 (#CL322-D3)
• BIONi010-C-85 (#CL324-A10)
• BIONi010-C-86 (BIONi010-C-5 (Trem2 R47H +/+) + microglia factors in AAVS1 and CLYBL)
• BIONi010-C-87 (BIONi010-C-5 (CD33 KO+/+) + microglia factors)
• BIONi010-C-88 (BIONi010-C + AAVS1-Cas9 + Insulators)
• BIONi010-C-89 (BIONi010-C + AAVS1-2N4R-MAPT-eGFP + Insulators)
• BIONi010-C-90 (BIONi010-C + AAVS1-2N4R-MAPT-P301L-eGFP + Insulators)
• BIONi010-C-91 (Inducible microglia cells with GRN KO EXP-22-AA8210 derived from: #CL502-A8)
• BIONi010-C-92 (BIONi010-C + AAVS1-eGFP + Ins (with deleted Poly-A), DOX inducible)
• BIONi010-C-93 (CD33 Exon2 deletion)
• BIONi010-C-94 (CD33 KO)
• BIONi010-C-95 (BIONi010-C; AAVS1; ASCL1-DXL2 (++); #CL294-B6; EXP-23-AA9614;)
• BIONi010-C-96 (BIONi010-C; AAVS1; MAFB-IRF8-CEBPa; (+/+); #CL502-A8; EXP-24-AA9645;)