Establishment of human induced pluripotent stem cell line from dermal fibroblasts of a healthy individual


Human-induced pluripotent stem cells (hiPSCs) are used to establish patient-specific cell lines and organs which are ideal models to mirror the pathological features of diseases in vitro and also, investigate the underlying mechanisms. It is essential to generate wild-type hiPSCs lines to optimize differentiation protocol and be also used, possibly, for cell therapy. In this study, hiPSCs were generated from the dermal fibroblasts of a 78-year-old healthy female individual using the non-genetic-integrated Sendai virus protocol, and characterized using standard validated methods. Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Huo Y, Wang J, He J, Kong D, Ma J
Journal Stem cell research
Publication Date 2020 Apr;44:101762
PubMed 32224419
DOI 10.1016/j.scr.2020.101762

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