Establishment and characterization of an iPSC line from a 35 years old high grade patient with nonalcoholic fatty liver disease (30-40% steatosis) with homozygous wildtype PNPLA3 genotype
Summary
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and its prevalence increases continuously. Here, we reprogrammed fibroblasts of a high grade NAFLD patient with homozygous wildtype PNPLA3 genotype. The induced pluripotent stem cells (iPSCs) were characterized by immunocytochemistry, flow cytometry, embryoid body formation, pluritest, DNA-fingerprinting and karyotype analysis. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Graffmann N, Bohndorf M, Ncube A, Kawala MA, Wruck W, Kashofer K, Zatloukal K, Adjaye J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2018 Aug;31:113-116 |
| PubMed | 30071394 |
| DOI | 10.1016/j.scr.2018.07.015 |