Establishment and characterization of an iPSC line from a 35 years old high grade patient with nonalcoholic fatty liver disease (30-40% steatosis) with homozygous wildtype PNPLA3 genotype


Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and its prevalence increases continuously. Here, we reprogrammed fibroblasts of a high grade NAFLD patient with homozygous wildtype PNPLA3 genotype. The induced pluripotent stem cells (iPSCs) were characterized by immunocytochemistry, flow cytometry, embryoid body formation, pluritest, DNA-fingerprinting and karyotype analysis. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Graffmann N, Bohndorf M, Ncube A, Kawala MA, Wruck W, Kashofer K, Zatloukal K, Adjaye J
Journal Stem cell research
Publication Date 2018 Aug;31:113-116
PubMed 30071394
DOI 10.1016/j.scr.2018.07.015

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