CRISPR/Cas9 mediated generation of a iPSC line EHTJUi005-A-1 with homozygous knockout of the SUV39H1 gene
Summary
SUV39H1 is a histone methyltransferase involve numerous biological processes, including of aging, embryo development, tumor growth and mitosis via catalysis of dimethylation and trimethylation of lysine 9 of histone H3. Here we report a human induced pluripotent stem cell line (EHTJUi005-A-1) which is generated from a wildtype human iPSC previously established in our laboratory, and this iPSC has a homozygous knockout of 8 bp in Exon 2 of SUV39H1. This iPSC model provides a valuable resource to study epigenetic regulation in extensive biological processes as mentioned above. Copyright © 2021. Published by Elsevier B.V.
| Authors | Qiao ZB, Lu JZ, Zhang L, Cao HX, Bai ZH, Qi YY, Zhu HY, Zhang SM, Bao Y, Jia WW, Liu ZM |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2021 Oct;56:102519 |
| PubMed | 34464854 |
| DOI | 10.1016/j.scr.2021.102519 |