CRISPR/Cas9 mediated generation of a iPSC line EHTJUi005-A-1 with homozygous knockout of the SUV39H1 gene
SUV39H1 is a histone methyltransferase involve numerous biological processes, including of aging, embryo development, tumor growth and mitosis via catalysis of dimethylation and trimethylation of lysine 9 of histone H3. Here we report a human induced pluripotent stem cell line (EHTJUi005-A-1) which is generated from a wildtype human iPSC previously established in our laboratory, and this iPSC has a homozygous knockout of 8 bp in Exon 2 of SUV39H1. This iPSC model provides a valuable resource to study epigenetic regulation in extensive biological processes as mentioned above. Copyright © 2021. Published by Elsevier B.V.
|Authors||Qiao ZB, Lu JZ, Zhang L, Cao HX, Bai ZH, Qi YY, Zhu HY, Zhang SM, Bao Y, Jia WW, Liu ZM|
|Journal||Stem cell research|
|Publication Date||2021 Oct;56:102519|