Generation of an induced pluripotent stem cell line, ZIPi021-A, from fibroblasts of a Prader-Willi syndrome patient with maternal uniparental disomy (mUPD)
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by loss of paternal expression of imprinted genes on chromosome 15q11-q13. We established a human induced pluripotent stem cell line (hiPSC), ZIPi021-A, from fibroblasts of a 4-year-old female PWS patient with the subtype of maternal uniparental disomy (mUPD). The generated hiPSC line was transgene-free, expressed pluripotency markers and showed the ability to differentiate into all three germ layers in vitro. The ZIPi021-A hiPSC line could be used as a cellular model for PWS in humans. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
|Authors||Heseding H, Jahn K, Brändl B, Haase A, Shum IO, Kohrn T, Bleich S, Frieling H, Martin U, Müller FJ, Wunderlich S, Deest M|
|Journal||Stem cell research|
|Publication Date||2023 Sep;71:103143|