Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA
Summary
We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Masano Y, Saegusa C, Ishikawa M, Matsunaga T, Okano H, Fujioka M |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Aug;78:103452 |
| PubMed | 38815527 |
| DOI | 10.1016/j.scr.2024.103452 |