Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation
Summary
We used a non-integrated reprogramming approach to establish a human induced pluripotent stem cell (hiPSC) line (INNDSUi011-A) from the skin fibroblasts of a 38-year-old female individual with autosomal dominant spastic paraplegia 9A due to ALDH18A1mutation. The cells obtained demonstrate key characteristics of embryonic stem cells, including the expression of specific pluripotency markers and the capacity to differentiate into the three germ layers in vitro. This iPSC cell line retains the patient's genetic information, making it a valuable model for studying disease mechanisms and developing novel therapies. Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Shan D, Wang H, Li J, Wang Y, Liu F |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Aug 14;87:103807 |
| PubMed | 40845627 |
| DOI | 10.1016/j.scr.2025.103807 |