Derivation of induced pluripotent stem cell TUSMi012-A from a 54-year-old Chinese Han with gliocytoma
Summary
A 54-year-old male gliocytoma patient donated peripheral blood mononuclear cells (PBMCs). These cells were reprogrammed using a non-integrating Sendai Virus with OKSM (OCT3/4, SOX2, KLF4, and c-MYC) transcription factors. The resulting iPSCs showed pluripotency markers via immunocytochemistry, maintained a normal karyotype, and could differentiate into three germ layers in vitro. This iPSC line is a valuable tool for studying gliocytoma pathogenesis and developing treatments. Copyright © 2025. Published by Elsevier B.V.
| Authors | Ma J, Zhuang Z, Yang C, Zhang B, Zhang K |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Jun 8;87:103753 |
| PubMed | 40516148 |
| DOI | 10.1016/j.scr.2025.103753 |