MCRIi019-A

Registration Summary:

A P E C

1502

The cell line is not submitted yet.

(only basic data is shown)

General

Cell Line
hPSCreg name	MCRIi019-A
Cite as:	MCRIi019-A (RRID:CVCL_A9XY)
Alternative name(s)	1502
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	21st February 2025
User feedback	Written by on No feedback available yet. Login to share your feedback, experiences or results with the research community.
Provider
Generator	Murdoch Children's Research Institute (MCRI)
External Databases
Cellosaurus	CVCL_A9XY
Wikidata	Q102114510
BioSamples	SAMEA117742037
General Information
Publications	Takasato Minoru et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature. 2015-10-22. (reference publication) Kung LHW et al. CRISPR/Cas9 editing to generate a heterozygous COL2A1 p.G1170S human chondrodysplasia iPSC line, MCRIi019-A-2, in a control iPSC line, MCRIi019-A. Stem cell research. 2020 Oct;48:101962. Kung LHW et al. Generation of a miR-26b stem-loop knockout human iPSC line, MCRIi019-A-1, using CRISPR/Cas9 editing. Stem cell research. 2020 Dec 10;50:102118. Lilianty J et al. Generation of a heterozygous COL2A1 (p.G1113C) hypochondrogenesis mutation iPSC line, MCRIi019-A-7, using CRISPR/Cas9 gene editing. Stem cell research. 2021 Oct;56:102515. Humphreys PA et al. Developmental principles informing human pluripotent stem cell differentiation to cartilage and bone. Seminars in cell & developmental biology. 2022 Jul;127:17-36. Shabaldin Nikita A. et al. Molecular foundations of the etiology and pathogenesis of Legg-Calve-Perthes disease and prospects for targeted therapy: A literature review. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2022-09-22. Yammine KM et al. Using CRISPR/Cas9 to generate a heterozygous COL2A1 p.R719C iPSC line (MCRIi019-A-6) model of human precocious osteoarthritis. Stem cell research. 2023 Mar;67:103020. Li ZA et al. Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential. Trends in biotechnology. 2023 Apr;41(4):511-527. Lamandé SR et al. Modeling human skeletal development using human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2023 May 9;120(19):e2211510120. Bombieri C et al. Advanced Cellular Models for Rare Disease Study: Exploring Neural, Muscle and Skeletal Organoids. International journal of molecular sciences. 2024 Jan 13;25(2). Ali Eltahir Abdelrazig Mohamed et al. iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review. Stem Cell Research & Therapy. 2024-06-26. Yammine KM et al. ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis. Life science alliance. 2024 Sep;7(9). Yammine Kathryn M. et al. Human cartilage model of the precocious osteoarthritis-inducingCOL2A1p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II. . 2024-11-09. Hojo Hironori et al. Modeling of skeletal development and diseases using human pluripotent stem cells. Journal of Bone and Mineral Research. 2024-12-31.
* Is the cell line readily obtainable for third parties?	No
Subclones	MCRIi019-A-1 MCRIi019-A-2 MCRIi019-A-3 MCRIi019-A-4 MCRIi019-A-5 MCRIi019-A-6 MCRIi019-A-7

hIPSC Derivation

General
Source cell line name	WS1 (ATCC CRL-1502)