Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential

Summary

Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA), afflict a substantial proportion of the global population. However, current clinical management has not been focused on fully restoring the native function of joints. Organ-on-chip (OoC), also called a microphysiological system, which typically accommodates multiple human cell-derived tissues/organs under physiological culture conditions, is an emerging platform that potentially overcomes the limitations of current models in developing therapeutics. Herein, we review major steps in the generation of OoCs for studying arthritis, discuss the challenges faced when these novel platforms enter the next phase of development and application, and present the potential for OoC technology to investigate the pathogenesis of joint diseases and the development of efficacious therapies. Copyright © 2022 Elsevier Ltd. All rights reserved.

Authors Li ZA, Sant S, Cho SK, Goodman SB, Bunnell BA, Tuan RS, Gold MS, Lin H
Journal Trends in biotechnology
Publication Date 2022 Aug 19;
PubMed 35995600
DOI 10.1016/j.tibtech.2022.07.011

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