MCRIi019-A-6

Registration Summary:

A P E C

1502-COL2A1 p.R719C

The cell line is not submitted yet.

(only basic data is shown)

General

Cell Line
hPSCreg name	MCRIi019-A-6
Cite as:	MCRIi019-A-6 (RRID:CVCL_D0HR)
Alternative name(s)	1502-COL2A1 p.R719C
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	9th January 2023
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Provider
Generator	Murdoch Children's Research Institute (MCRI)
External Databases
Cellosaurus	CVCL_D0HR
Wikidata	Q123033010
General Information
Publications	Yammine KM et al. Using CRISPR/Cas9 to generate a heterozygous COL2A1 p.R719C iPSC line (MCRIi019-A-6) model of human precocious osteoarthritis. Stem cell research. 2023 Mar;67:103020. Yammine KM et al. ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis. Life science alliance. 2024 Sep;7(9). Yammine Kathryn M. et al. Human cartilage model of the precocious osteoarthritis-inducingCOL2A1p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II. . 2024-11-09.
Subclone of	MCRIi019-A

hIPSC Derivation

General
The source cell information can be found in the parental cell line MCRIi019-A.