MCRIi019-A-2

iPSC Line

Provider

External iPSC Databases

General iPSC Information

• Kung LHW et al. CRISPR/Cas9 editing to generate a heterozygous COL2A1 p.G1170S human chondrodysplasia iPSC line, MCRIi019-A-2, in a control iPSC line, MCRIi019-A. Stem cell research. 2020 Oct;48:101962.
• Kung LHW et al. Generation of a miR-26b stem-loop knockout human iPSC line, MCRIi019-A-1, using CRISPR/Cas9 editing. Stem cell research. 2021 Jan;50:102118.
• Lilianty J et al. Generation of a heterozygous COL2A1 (p.G1113C) hypochondrogenesis mutation iPSC line, MCRIi019-A-7, using CRISPR/Cas9 gene editing. Stem cell research. 2021 Oct;56:102515.
• Humphreys PA et al. Developmental principles informing human pluripotent stem cell differentiation to cartilage and bone. Seminars in cell & developmental biology. 2022 Jul;127:17-36.
• Shabaldin Nikita A. et al. Molecular foundations of the etiology and pathogenesis of Legg-Calve-Perthes disease and prospects for targeted therapy: A literature review. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2022-09-22.
• Yammine KM et al. Using CRISPR/Cas9 to generate a heterozygous COL2A1 p.R719C iPSC line (MCRIi019-A-6) model of human precocious osteoarthritis. Stem cell research. 2023 Mar;67:103020.
• Lamandé SR et al. Modeling human skeletal development using human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2023 May 9;120(19):e2211510120.
• Yammine KM et al. ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis. Life science alliance. 2024 Sep;7(9).
• Hojo Hironori et al. Modeling of skeletal development and diseases using human pluripotent stem cells. Journal of Bone and Mineral Research. 2024-12-31.
• Yammine KM et al. Failed cellular surveillance enables pathogenic matrix deposition in a COL2A1-related osteoarthritis. The Journal of biological chemistry. 2025 Aug;301(8):110436.

• MCRIi019-A

General