MCRIi019-A-2

Registration Summary:

A P E C

1502-COL2A1p.G1170S

The cell line is not submitted yet.

(only basic data is shown)

General

Cell Line
hPSCreg Name	MCRIi019-A-2
Alternative name(s)	1502-COL2A1p.G1170S
Cell line type	Human induced pluripotent stem cell (hiPSC)
Last update	1st September 2022
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Provider
Generator	Murdoch Children's Research Institute (MCRI) Contact: Murdoch Children's Research Institute (MCRI)
Owner	Murdoch Children's Research Institute (MCRI)
Distributors	Murdoch Children's Research Institute (MCRI)
External Databases
Cellosaurus	CVCL_A9XZ
Wikidata	Q102114511
General Information
Publications	Kung LHW et al. CRISPR/Cas9 editing to generate a heterozygous COL2A1 p.G1170S human chondrodysplasia iPSC line, MCRIi019-A-2, in a control iPSC line, MCRIi019-A. Stem cell research. 2020 Oct;48:101962. Kung LHW et al. Generation of a miR-26b stem-loop knockout human iPSC line, MCRIi019-A-1, using CRISPR/Cas9 editing. Stem cell research. 2020 Dec 10;50:102118. Lilianty J et al. Generation of a heterozygous COL2A1 (p.G1113C) hypochondrogenesis mutation iPSC line, MCRIi019-A-7, using CRISPR/Cas9 gene editing. Stem cell research. 2021 Oct;56:102515. Humphreys PA et al. Developmental principles informing human pluripotent stem cell differentiation to cartilage and bone. Seminars in cell & developmental biology. 2022 Jul;127:17-36. Shabaldin Nikita A. et al. Molecular foundations of the etiology and pathogenesis of Legg-Calve-Perthes disease and prospects for targeted therapy: A literature review. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2022-09-22.
Subclone of	MCRIi019-A

hIPSC Derivation

General
The source cell information can be found in the parental cell line MCRIi019-A.