Generation of induced pluripotent stem cells (NIMHi015-A) from a Parkinson's Disease patient harbouring a homozygous Exon 3 deletion in the PRKN gene
Summary
The Parkin (PRKN) gene mutation is prevalent in young-onset Parkinson's disease (PD), typically emerging before age 30, accompanied by early motor symptoms. Induced pluripotent stem cells (iPSCs) were derived from peripheral blood mononuclear cells of a PD patient with an exon 3 deletion in PRKN using Sendai-virus reprogramming. PD diagnosis was confirmed via the Unified Parkinson's Disease Rating Scale (UPDRS). Characterization of the iPSC line ensured self-renewal and pluripotency. This resource serves as a valuable platform for drug screening and elucidating the pathophysiology of this mutation, facilitating advancements in PD research. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Banerjee R, Ghanty R, Jagtap S, Holla V, Kamble N, Yadav R, Pal PK, Datta I |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Jun;77:103440 |
| PubMed | 38739971 |
| DOI | 10.1016/j.scr.2024.103440 |