Generation of induced pluripotent stem cells (ZZUCSBi001-A) from skin fibroblasts of a healthy donor
Summary
Fibroblasts were extracted from the scalp of a healthy 55-year-old male and subsequently transformed into pluripotent stem cells by introducing episomal plasmids harboring essential reprogramming factors. These induced pluripotent stem cells exhibited a normal karyotype and demonstrated the capacity to differentiate into all three germ layers, as confirmed through teratoma assays. This specific cell line serves as a valuable reference for comparative investigations alongside other induced pluripotent stem cell lines generated from somatic cells of patients afflicted by genetic neurodegenerative disorders. Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Li SA, Zhang YJ, Zhu YQ, Meng XY, Chen CL, Liu PP, Sun W |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2024 Apr;76:103328 |
| PubMed | 38335661 |
| DOI | 10.1016/j.scr.2024.103328 |