Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
Summary
Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Bai X, Yang XJ, Chen L |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2019 Aug;39:101495 |
| PubMed | 31376721 |
| PubMed Central | PMC7077977 |
| DOI | 10.1016/j.scr.2019.101495 |