Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia


Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Bai X, Yang XJ, Chen L
Journal Stem cell research
Publication Date 2019 Aug;39:101495
PubMed 31376721
PubMed Central PMC7077977
DOI 10.1016/j.scr.2019.101495

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