Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
|Authors||Bai X, Yang XJ, Chen L|
|Journal||Stem cell research|
|Publication Date||2019 Aug;39:101495|