Establishment of a human DOA 'plus' iPSC line, IISHDOi003-A, with the mutation in the OPA1 gene: c.1635C>A; p.Ser545Arg
Summary
We have generated a human iPSC line IISHDOi003-A from fibroblasts of a patient with a dominant optic atrophy 'plus' phenotype, harbouring a heterozygous mutation, c.1635C>A; p.Ser545Arg, in the OPA1 gene. Reprogramming factors Oct3/4, Sox2, Klf4, and c-Myc were delivered using Sendai virus. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zurita-Díaz F, Galera-Monge T, Moreno-Izquierdo A, Corton M, Ayuso C, Garesse R, Gallardo ME |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2017 Oct;24:81-84 |
| PubMed | 29034899 |
| DOI | 10.1016/j.scr.2017.08.017 |