Establishment of induced pluripotent stem cell line (GSPHi001-A) from a 6-year old female with nephrotic syndrome


Peripheral blood mononuclear cells (PBMCs) were collected from a 6-year-old female child who was clinically diagnosed as primary nephrotic syndrome (NS) with hormone resistance. An iPSC line was successfully established by the Sendai-virus (SeV) delivery system. The iPS-19 (GSPHi001-A) expressed pluripotent markers, exhibited a normal karyotype and differentiated towards three germ layers. The iPSC line might offer a potentially useful tool for investigating mechanisms of primary NS, drug testing and gene therapy studies. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Gao X, Gao X, Zhao H, Cui W, Tan M, Deng H
Journal Stem cell research
Publication Date 2019 Dec;41:101661
PubMed 31759290
DOI 10.1016/j.scr.2019.101661

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