Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2
Summary
This study demonstrates JPH2's essential role in sustaining excitation-contraction coupling by stabilizing the junctional membrane complex, with its deficiency driving heart failure-like cardiac dysfunction. ECCD is established as a sensitive, comprehensive indicator for assessing JPH2-related impairment severity. These findings advance our understanding of JPH2 in cardiac pathology and position ECCD as a valuable tool for research and potential clinical evaluation, with JPH2 and calcium regulation emerging as promising therapeutic targets. © 2025. The Author(s).
| Authors | Guo T, Wang H, Wu F, Lu W, Zhu M, Ma S, Zhang Y, Yan Y, Zhou M, Talanaite D, Liu S, Qi M, Lan F, Liu X |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2025 May 9;16(1):234 |
| PubMed | 40346697 |
| PubMed Central | PMC12065164 |
| DOI | 10.1186/s13287-025-04323-4 |