Generation of human induced pluripotent stem cells from peripheral blood mononuclear cells of a Senior-Loken syndrome patient


Senior-Loken syndrome (SLS) is a rare disorder primarily associated with kidney and retinal dysfunction. We generated a human induced pluripotency stem cell (hiPSC) line, designated DKHi005-A, from peripheral blood mononuclear cells of a patient with SLS using a Sendai virus reprogramming method. We confirmed that DKHi005-A cells harbor the same mutation as the patient and show a normal karyotype. DKHi005-A also has pluripotency and the capacity for differentiation into the three germ layers. This cell line is registered and available at the National Stem Cell Bank, Korea National Institute of Health. Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Park H, Han J, Lee Y, Kwak S, Koo SK
Journal Stem cell research
Publication Date 2019 Dec;41:101648
PubMed 31734643
DOI 10.1016/j.scr.2019.101648

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