Establishment of an induced pluripotent stem cell line (ZZUSAHi002-A) derived from peripheral blood mononuclear cells of a healthy individual


Peripheral blood mononuclear cells (PBMCs) were isolated from a 32-year-old female and were reprogrammed to human induced pluripotent stem cells (iPSCs) using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The ZZUSAHi002-A iPSC line expresses pluripotency markers, exhibits a normal female karyotype (46, XX) and has the capacity to differentiate into three germ layers in vivo. This iPSC line may be used for cell transplantations, drug testing and biological tissue engineering. Copyright © 2020. Published by Elsevier B.V.

Authors Liu S, Niu S, Li Y, Xiong H, Li Y, Jian L, Zhang L
Journal Stem cell research
Publication Date 2020 Oct;48:101966
PubMed 32911326
DOI 10.1016/j.scr.2020.101966

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