LVIP04-LC12-1-BE1
The cell line is not submitted yet.
(only basic data is shown)
General
Cell Line |
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| hPSCreg name | LVPEIi006-B-1 |
| Cite as: | LVPEIi006-B-1 |
| Alternative name(s) |
LVIP04-LC12-1-BE1
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| Cell line type | Human induced pluripotent stem cell (hiPSC) |
| Similar lines | No similar lines found. |
| Last update | 12th February 2025 |
| Notes | This is an isogenic, heterozygous, mutation-corrected iPSC line (LVPEIi006-B-1), using an engineered en31FnCas9-based adenine base editor system. The isogenic line was clonally expanded beyond passage 20 and genotyped to confirm the desired base correction. This line maintained its stemness, pluripotency, genomic integrity and could differentiate into retinal organoids. The correction of pathogenic mutation in one of the two alleles resulted in partial restoration of normal RD3 mRNA splicing in the retinal organoids. |
| User feedback | |
Provider |
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| Generator |
L.V. Prasad Eye Institute (LVPEI)
Contact:
L.V. Prasad Eye Institute (LVPEI) |
| Owner | L.V. Prasad Eye Institute (LVPEI) |
| Distributors | |
External Databases |
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| BioSamples | SAMEA117688009 |
General Information |
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| * Is the cell line readily obtainable for third parties? |
Yes Research use: allowed
Clinical use: not allowed
Commercial use: allowed
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| Subclone of | |
hIPSC Derivation
General |
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The source cell information can be found in the parental cell line
LVPEIi006-B.
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