Establishment of human embryonic stem cell WAe009-A-74 carrying a Long QT syndrome mutation in KCNH2


Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear. Herein, we have generated a human embryonic stem cell line (WAe009-A-74) carrying a LQTS related mutation in KCNH2. The WAe009-A-74 line maintained stem cell like morphology, pluripotency, normal karyotype and could differentiate into all three germ layers in vivo. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Sun L, Zhong J, Wu F, Li F, Yang X, Zeng Z
Journal Stem cell research
Publication Date 2022 Apr;60:102725
PubMed 35247842
DOI 10.1016/j.scr.2022.102725

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