Generation of a human induced pluripotent stem cell line (UMGACBi001-A) from urine cells of a chronic kidney disease patient with hypertension, diabetic nephropathy and acute sepsis
Summary
Chronic kidney disease is a major public health burden associated with a drastically reduced quality of living and life span that lacks suitable, individualized therapeutic strategies. Here we present a human induced pluripotent stem cell line (iPSC, UMGACBi001-A) reprogrammed from urine cells of an acute septic dialysis patient suffering from chronic kidney disease using non-integrating administration of RNAs. The generated iPSCs were positively characterized for typical morphology, pluripotency marker expression, directed differentiation potential, non-contamination, chromosomal consistency and donor identity. This iPSC-line can be a useful source for in vitro disease modelling and individualized therapeutic approaches. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Lange T, Bach SM, Koppe TM, Klann A, Weise A, Alexander Pilz R, Loth N, Rheinbaben SV, Stracke S, Endlich N |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2023 Dec;73:103224 |
| PubMed | 38323759 |
| DOI | 10.1016/j.scr.2023.103224 |