Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3


Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line "KUMi003-A" from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Kim JH, Kang KW, Lee BH, Park Y, Kim BS
Journal Stem cell research
Publication Date 2022 Aug;63:102861
PubMed 35905670
DOI 10.1016/j.scr.2022.102861

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