Generation of induced pluripotent stem cells from two ADHD patients and two healthy controls


Attention-deficit hyperactivity disorder is a neurodevelopmental disorder which prevalence has been increasing in the past decades, affecting more than 5% of children, adolescents worldwide. Regarding etiology, polygenic, environmental factors contribute to the occurrence of ADHD even though molecular mechanisms are not known. Understanding the pathophysiology in patient-specific cells is crucial for the discovery of potential predictive markers, the establishment of new therapeutic targets. In this study, we generated further lines from ADHD patients, healthy controls using Sendai virus transduction, which may help on the study of ADHD at the molecular, cellular levels. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

Authors Yde Ohki CM, Walter NM, Rickli M, Van Puyenbroeck P, Döring C, Hoffmann P, Herms S, Maria Werling A, Walitza S, Grünblatt E
Journal Stem cell research
Publication Date 2023 Jun;69:103084
PubMed 37004448
DOI 10.1016/j.scr.2023.103084

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