Generation of two iPSC lines (FAMRCi006-A and FAMRCi006-B) from patient with dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy associated with genetic variant LMNAp.Arg527Pro


Mutations in LMNA gene are known to cause a broad range of diseases called laminopathies. We have generated two induced pluripotent stem cell lines FAMRCi006-A and FAMRCi006-B from a patient carrying LMNA p. p.Arg527Pro mutation associated with Emery-Dreifuss muscular dystrophy and dilated cardiomyopathy. Patient-specific peripheral blood mononuclear cells were reprogrammed to iPSCs using Sendai virus reprogramming system. Characterization of iPSCs had revealed pluripotency marker expression, normal karyotype, ability to differentiate into three embryonic germ layers. The reported iPSC lines could be a useful tool for in vitro modeling of laminopathies associated with LMNA genetic variants. Copyright © 2020. Published by Elsevier B.V.

Authors Perepelina K, Klauzen P, Khudiakov A, Zlotina A, Fomicheva Y, Rudenko D, Gordeev M, Sergushichev A, Malashicheva A, Kostareva A
Journal Stem cell research
Publication Date 2020 Mar;43:101714
PubMed 32059175
DOI 10.1016/j.scr.2020.101714

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