Generation of a human induced pluripotent stem cell line derived from a patient with dilated cardiomyopathy carrying LMNA nonsense mutation
Summary
Dilated cardiomyopathy (DCM) is a refractory heart disease characterized by dilation of the left ventricle and systolic dysfunction. LMNA, the gene encoding lamin A/C (a nuclear envelope protein), is the second leading causative gene associated with familial DCM. LMNA-related DCM is likely to develop severe heart failure, various types of arrhythmias, and poor prognosis. We established a human induced pluripotent stem cell line, derived from a patient with DCM carrying a nonsense mutation in LMNA. This line should be a useful resource for elucidating disease mechanisms and developing fundamental treatments for LMNA-related DCM. Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Shimoda Y, Murakoshi N, Mori H, Xu D, Tajiri K, Hemmi Y, Sato I, Noguchi M, Nakamura Y, Hayashi Y, Ieda M |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Jul;62:102793 |
| PubMed | 35500377 |
| DOI | 10.1016/j.scr.2022.102793 |