Establishment of TUSMi005-A, an induced pluripotent stem cell (iPSC) line from a 32-year old Chinese Han patient with Bipolar Disorder (BD)


A 32-year old Bipolar Disorder (BD) male patient donated his Peripheral blood mononuclear cells (PBMC). The non-integrating episomal vector system used to reprogram PBMCs with the human OKSM transcription factors. The pluripotency of transgene-free iPSCs was confirmed by immunocytochemistry for pluripotency markers and by the ability of the iPSCs to differentiate spontaneously into 3 germ layers in vitro. In addition, the iPSC line displayed a normal karyotype. Our model might offer a good platform to further study the pathological mechanisms, to identify early biomarkers, and also for drug testing studies in BD. Resource table. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Wang Y, Fen Q, Yu H, Qiu H, Ma X, Lei Y, Zhao J
Journal Stem cell research
Publication Date 2018 Dec;33:65-68
PubMed 30316949
DOI 10.1016/j.scr.2018.10.014

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