Generation of induced pluripotent stem cell line (ZZUi019-A) derived from skin fibroblasts from a healthy volunteer


The research on nervous system diseases is limited by the difficulty in obtaining nerve cells from humans. The development of induced pluripotent stem cells (iPSCs) technology and the experimental system provide a feasible method for directional induced differentiation of nerve cells in vitro. In this project, we recruited a 50-year-old Han Chinese man as a healthy volunteer, and successfully constructed his skin fibroblast-derived iPSCs using the non-integrated reprogramming method. At the same time, the related pluripotency identification experiments were completed. This cell line will be included in the normal control group in follow-up experiments, providing an important reference for the study of neurological diseases. Copyright © 2021. Published by Elsevier B.V.

Authors Wang Y, Sun H, Wang Z, Zhang Q, Yang J, Liu Y, Liu H, Shi C, Wang Y, Xu Y
Journal Stem cell research
Publication Date 2021 Mar 12;53:102285
PubMed 33740644
DOI 10.1016/j.scr.2021.102285

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