Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5)
Summary
Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal developmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (iPSC) derivatives have been used as a research tool to investigate autologous regenerative medicine. Here, we reprogrammed cynomolgus monkey kidney fibroblasts (cmKFs) as a control for animal iPSCs and to study autologous transplant. The resulting cmKF-iPSCs, which displayed canonical characteristics of PSCs, could be used as a unique model for autologous cell-based therapy. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Zhen X, Kang W, Park SJ, Choe SH, Hong SH, Lee DS, Lee JH |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2022 Oct;64:102887 |
| PubMed | 35944314 |
| DOI | 10.1016/j.scr.2022.102887 |