Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5)


Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal developmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (iPSC) derivatives have been used as a research tool to investigate autologous regenerative medicine. Here, we reprogrammed cynomolgus monkey kidney fibroblasts (cmKFs) as a control for animal iPSCs and to study autologous transplant. The resulting cmKF-iPSCs, which displayed canonical characteristics of PSCs, could be used as a unique model for autologous cell-based therapy. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Authors Zhen X, Kang W, Park SJ, Choe SH, Hong SH, Lee DS, Lee JH
Journal Stem cell research
Publication Date 2022 Aug 3;64:102887
PubMed 35944314
DOI 10.1016/j.scr.2022.102887

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