Lab resource: Single cell line - template: Establishment of an induced pluripotent stem cell (iPSC) line (JNMUi003-A) from a male patient with schizophrenia
Summary
We generated an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells obtained from a 41-year-old male patient diagnosed with schizophrenia using non-integrating reprogramming techniques. The iPSC lines exhibited normal karyotypes, expressed specific markers of pluripotency, and demonstrated the capacity to differentiate into all three germ layers in vitro. This cell line will serve as a valuable in vitro model for investigating the underlying pathophysiological mechanisms of this disease and identifying novel therapeutic approaches. Copyright © 2025. Published by Elsevier B.V.
| Authors | Liu Y, Li R, Long Y, Jiang M, Xu J, Chi T, Zhang X, Yu H, Han X |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2025 Feb 11;84:103679 |
| PubMed | 39955799 |
| DOI | 10.1016/j.scr.2025.103679 |